THCP vs Cannabinoids

CBD Cannabis graph

THCP vs Cannabinoids: A Comprehensive Comparison



THCP stands for tetrahydrocannabiphorol. It was discovered as recently as 2019, so there hasn’t been much (if any) official research on its effects quite yet. The only research we do have has been exploring its safety and potency using animal and in vitro cell cultures.

THCP exists naturally in cannabis plants — albeit in very low concentrations. It can be extracted and isolated from hemp and marijuana using chromatography techniques.


THC-O is the esters version of THC, Meaning its THC that has been altered at a molecular level, using acetic anhydride and sulfuric acid to create THCO. You’ll also find THCO frequently named as

  • THC-O Acetate
  • ATHC

THC and THCP share nearly identical chemical structures with one crucial difference: the length of their alkyl side chain. THC’s chain is a five-carbon atom chain, while THCP’s has seven carbon atoms.

Besides being an interesting piece of trivia, this structural difference makes THCP significantly more biologically active. THCP’s longer side-chain gives it 30 times higher bonding activity at cannabinoid type one (CB1) receptors, making it potentially 30 times more potent than THC.

THCP is the new powerhouse cannabinoid on the block. THCP, which is short for tetrahydrocannabiphorol and scientifically known as (-)-Trans-Δ9-tetrahydrocannabiphorol, is a natural cannabinoid and analog of THC present in varieties of cannabis.

THCP (Δ9-Tetrahydrocannabiphorol) is one of the newest cannabinoids to hit the global hemp stage.

  • THC-O is a synthetic cannabinoid
  • THCP is a natural Phytocannabinoids

Scientifically, natural cannabinoids are called Phytocannabinoids.

The human body also produces its own set of cannabinoids, and these are known as endogenous cannabinoids (endocannabinoid).

Yet the high with THC-O also tends to last longer than with THCP.

Natural Phytocannabinoids

A shortlist of natural cannabinoids produced by the Cannabis Sativa plant family,

  • CBD
  • Delta 8 THC
  • THC-P
  • CBG
  • CBN
  • THCV

Some of these cannabinoids occur in smaller amounts than others. For example, CBD and THC are the two most abundant cannabinoids.

Semi-synthetic Cannabinoids

Semi-synthetic cannabinoids often occur naturally in cannabis plants but only in small amounts.

Since the conversion is not a natural process that occurs within the cannabis plant itself, these cannabinoids are termed semi-synthetic:

  • Delta 10 THC 
  • THC-O
  • HHC


It’s stronger (almost psychedelic), so you need a smaller dose to experience the same general effects as THC.

THCP is 30 times more biologically active than THC and, therefore, also has proportionally stronger effects. 

This means the dose of THCP and THC are going to be very different.

As such, it is important to tread lightly, especially if you’ve ever experienced adverse side effects from THC use, like paranoia, memory loss, or became just way to high. 


THCP works by interacting with your body’s endocannabinoid system. The endocannabinoid primarily has two kinds of receptors: cannabinoid receptor type one (CB1) and cannabinoid type 2 (CB2) receptors.

CB1 and CB2 receptors behave differently and create different effects.

THCP works by interacting with your body’s endocannabinoid system. The endocannabinoid primarily has two kinds of receptors: cannabinoid receptor type one (CB1) and cannabinoid type 2 (CB2) receptors. CB1 and CB2 receptors behave differently and create different effects.

CB1 receptors are located in the nervous system and are responsible for the psychoactive properties of THC and THCP.

Like THC, THCP is a strong CB1 agonist, meaning it binds with the receptor and causes an psychoactive effect. Since THC and THCP have the same CB1 behavior, their pharmacological effects are similar.




THCP is much, much stronger than Delta 8 THC (roughly 60 times as strong).

The effects of these cannabinoids are very different as well. THCP can be quite stimulating. This, combined with its exceptional potency, makes THCP very likely to result in nervous side effects, like feeling caffeine out, and sped up.

Delta 8 is the total opposite — it’s has a milder and far more mellow feeling. Delta 8 THC is unlikely to make users feel uneasy or negatively affect your slumber.


THCP and Delta 9 THC have essentially the same effects. The only difference is the potency levels.

The normal dose of delta 9 THC is around 10 mg. The equivalent dose of THCP is closer to 0.3 mg (300 micrograms). You don’t even need a full milligram of THCP for potent effects.

Because of how strong THCP is, it’s much more likely to lead to side effects than conventional THC products.


Delta 10 THC is generally used during the day as a sort of nootropic. It’s more stimulating than delta 8 THC and delta 9 THC without affecting headspace too much.

Compared to THCP, Delta-10 THC is much milder and has far less impact on headspace. THCP will really alter your cranial capacity to do stuff like work or study while delta 10 THC (in low to moderate doses) is often used to enhance it.


THCO is another exceptionally potent cannabinoid (roughly three times as potent as Delta-9 THC and nearly six times as potent as Delta 8 THC). 

The main differences between THCP and THCO involve the origin (THCP is naturally occurring, THCO is fully synthetic), the onset time (THCP kicks in right away, THCO has a delay), and the potency (THCP is around 10 times stronger than THCO).


HHC (Hexahydrocannabinol) is another new cannabinoid to enter the market. This one is much more similar to Delta 9 than THCP. HHC shares virtually identical effects as D9 THC and is only slightly weaker.

You may just need an extra puff or two on an HHC vapid to get the same intensity of effects as Delta 9 THC.

What are the side-effects of THCP?

THCP is similar to THC we can assume side-effects are similar between the two. Common THC side-effects include.

  • Dry Mouth
  • Self-consciousness
  • Sleepiness
  • Red eyes
  • Intoxicating 

CBD Direct carries a wide arrange of THCP blends. Visit our website today!

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